Research Article A new Informatics Framework for Evaluating the Codon Usage Metrics, Evolutionary Models and Phylogeographic reconstruction of Tomato yellow leaf curl virus (TYLCV) in different regions of Asian countries

Tomato yellow leaf curl virus (TYLCV) is a major devastating viral disease, majorly affecting the tomato production globally. The disease transmitted by Whitefly. Begomovirus having six protein coding genes, among them C1/AC1 evidently associated with replication. Owing to immense role of gene, present study an initial effort elucidate factors shaping codon usage bias and evolutionary pattern TYLCV-C1/AC1 gene in five Asian countries. Based on publically available nucleotide sequence data Codon pattern, Evolutionary Phylogeographic reconstruction was carried out. revealed presence significant variation between indices all selected regions. Implying that (eNC, CAI, RCDI, GRAVY, Aromo) are seriously affected selection mutational pressure, taking supremacy gene. Further, tMRCA age 1853, 1939, 1855, 1944, 1828 for China, India, Iran, Oman South Korea, respectively integrated analysis bias, rate Phylogeography viruses signifies positive pressure regions TYLCV (C1/AC1)